Why the study?
Does Roux-en-Y gastric bypass reduce blood pressure and alter MRproANP levels in hypertensive, morbidly obese patients?
Does Roux-en-Y gastric bypass reduce blood pressure and alter MRproANP levels in hypertensive, morbidly obese patients?
Roux-en-Y gastric bypass significantly reduces blood pressure and increases MRproANP levels at 6 weeks, suggesting a link between obesity-hypertension and natriuretic peptide regulation.
Short-term BP reduction with MRproANP rise after LRYGB in obese hypertensives is hypothesis-generating; RCTs needed before practice change.
LRYGB resulted in a significant 24BP reduction and a substantial increase in MRproANP plasma concentrations in hypertensive, obese patients 6 weeks after surgery, suggesting a causal link between obesity-hypertension and altered release/degradation of cardiac natriuretic peptides.
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Bonfils et al. (2015) studied this question.
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