CASQ2 modulation of hERG channels and cytosolic calcium may play a mechanistic role in the etiology of catecholaminergic polymorphic ventricular tachycardia (CPVT).
Hypothesis-generating for CASQ2-hERG crosstalk in CPVT; should not yet inform clinical practice.
These in vitro and in silico data suggest a regulatory role of CASQ2 on cytosolic Ca(2+) and hERG channels which may contribute to the etiology of CPVT.
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Eckey et al. (2010) studied this question.
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