Why the study?
Defining transcriptional and cellular diversity in the normal human heart is needed to identify discrete cell subtypes and differentially expressed genes to facilitate cardiovascular therapeutic development.
Provides a foundational map of transcriptional and cellular diversity in the normal human heart to facilitate future cardiovascular therapeutic development.
Reference atlas of normal cardiac cells now available; leaves open extension to disease states and therapeutic translation.
Using large-scale single nuclei RNA sequencing, we defined the transcriptional and cellular diversity in the normal human heart. Our identification of discrete cell subtypes and differentially expressed genes within the heart will ultimately facilitate the development of new therapeutics for cardiovascular diseases.
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Tucker et al. (2020) studied this question.
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