Why the study?
Does circulatory support with an LVAD improve the functional properties of myocytes from failing human hearts?
Population
Myocytes isolated from human explanted failing hearts and failing hearts with antecedent LVAD support
Comparison
Antecedent left ventricular assist device support vs No antecedent LVAD support
Design
Preclinical
Authors
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LVAD support may enhance myocyte contractility in HF; hypothesis-generating and leaves open human translation.
Does circulatory support with an LVAD improve the functional properties of myocytes from failing human hearts?
Circulatory support with an LVAD improves myocyte contractile properties and increases beta-adrenergic responsiveness in patients with end-stage heart failure.
Δίπλα et al. (1998) studied this question.
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