November 28, 2000Circulation
Chronic Unloading by Left Ventricular Assist Device Reverses Contractile Dysfunction and Alters Gene Expression in End-Stage Heart Failure
Why the study?
Does LVAD support improve contractile strength and alter calcium-handling gene expression in patients with end-stage heart failure?
Population
Patients with end-stage heart failure.
Comparison
Left ventricular assist device (LVAD) support vs End-stage heart failure without LVAD support, or…
Design
Cohort
Authors
Discussion
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Member takes
Implication
LVAD unloading may support reverse remodeling in end-stage HF; leaves open whether SERCA2a changes improve clinical outcomes.
Structured PICO
Does LVAD support improve contractile strength and alter calcium-handling gene expression in patients with end-stage heart failure?
P
Population
Patients with end-stage heart failure (n=15 without LVAD, n=7 with LVAD for force-frequency relationship analysis; n=20 paired samples before and after LVAD for gene expression analysis).
I
Intervention
Left ventricular assist device (LVAD) support
C
Comparator
End-stage heart failure without LVAD support, or pre-LVAD baseline (paired analysis)
O
Outcome
Contractile strength (force-frequency relationship) and expression of genes/proteins involved in Ca2+ handling (SERCA2a, ryanodine receptor, Na+-Ca2+ exchanger)surrogate
LVAD support in end-stage heart failure reverses contractile dysfunction and induces reverse molecular remodeling by upregulating SERCA2a protein and improving calcium handling.
Cite This Study
Heerdt et al. (2000) studied this question.