November 28, 2000Circulation

Chronic Unloading by Left Ventricular Assist Device Reverses Contractile Dysfunction and Alters Gene Expression in End-Stage Heart Failure

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Why the study?

Does LVAD support improve contractile strength and alter calcium-handling gene expression in patients with end-stage heart failure?

Structured PICO

Does LVAD support improve contractile strength and alter calcium-handling gene expression in patients with end-stage heart failure?

Population

Patients with end-stage heart failure (n=15 without LVAD, n=7 with LVAD for force-frequency relationship analysis; n=20 paired samples before and after LVAD for gene expression analysis).

Intervention

Left ventricular assist device (LVAD) support

Comparator

End-stage heart failure without LVAD support, or pre-LVAD baseline (paired analysis)

Outcome

Contractile strength (force-frequency relationship) and expression of genes/proteins involved in Ca2+ handling (SERCA2a, ryanodine receptor, Na+-Ca2+ exchanger)surrogate

LVAD support in end-stage heart failure reverses contractile dysfunction and induces reverse molecular remodeling by upregulating SERCA2a protein and improving calcium handling.

Discussion

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Implication

LVAD unloading may support reverse remodeling in end-stage HF; leaves open whether SERCA2a changes improve clinical outcomes.

Cite This Study

Heerdt et al. (2000) studied this question.

synapsesocial.com/papers/6a1fd55d663eb9633f117cf9 https://doi.org/10.1161/01.cir.102.22.2713

Topics

Mechanical circulatory support Heart failure HFrEF treatment

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Chronic Unloading by Left Ventricular Assist Device Reverses Contractile Dysfunction and Alters Gene Expression in End-Stage Heart Failure

Structured PICO

Discussion

Implication

Cite This Study

Topics

Chronic Unloading by Left Ventricular Assist Device Reverses Contractile Dysfunction and Alters Gene Expression in End-Stage Heart Failure

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider