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June 30, 2003European Heart JournalOpen Access

Changes in sarcolemmal Ca entry and sarcoplasmic reticulum Ca content in ventricular myocytes from patients with end-stage heart failure following myocardial recovery after combined pharmacological and ventricular assist device therapy

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Why the study?

Does combined pharmacological and LVAD therapy improve cellular Ca handling in ventricular myocytes from patients with end-stage heart failure?

Population

Ventricular myocytes from patients with end-stage heart failure

Comparison

Combined pharmacological and left ventricular… vs Failing left ventricular tissue taken at LVAD…

Design

Preclinical

Authors

CTCesare M. Terracciano

Discussion

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Overview

Supports LVAD-pharmacotherapy for myocyte recovery in end-stage HF; leaves open clinical translation.

Structured PICO

Does combined pharmacological and LVAD therapy improve cellular Ca handling in ventricular myocytes from patients with end-stage heart failure?

P
Population
Ventricular myocytes from patients with end-stage heart failure
I
Intervention
Combined pharmacological and left ventricular assist device (LVAD) therapy (myocytes taken at LVAD removal)
C
Comparator
Failing left ventricular tissue taken at LVAD implant (LVAD core)
O
Outcome
Changes in Ca handling at the cellular level, including cell size, sarcolemmal Ca entry, and sarcoplasmic reticulum (SR) Ca contentsurrogate

Myocardial recovery after LVAD and pharmacological therapy is associated with improved cellular calcium handling and regression of cellular hypertrophy in end-stage heart failure.

Cite This Study

Cesare M. Terracciano (2003) studied this question.

synapsesocial.com/papers/6a6f6fa4febe604dd7085a98https://doi.org/10.1016/s0195-668x(03)00242-2
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cellular Basis of Abnormal Calcium Transients of Failing Human Ventricular Myocytes2003 · 482 citations
  2. 2Restoration of Contractile Function in Isolated Cardiomyocytes From Failing Human Hearts by Gene Transfer of SERCA2a1999 · 508 citations
  3. 3Reduced Contraction and Altered Frequency Response of Isolated Ventricular Myocytes From Patients With Heart Failure1995 · 209 citations
  4. 4Gene expression of the cardiac Na(+)-Ca2+ exchanger in end-stage human heart failure.1994 · 635 citations
  5. 5Contractile Function and Response to Agonists in Myocytes from Failing Human Heart1994 · 13 citations