Comparison of Right and Left Ventricular Responses to Left Ventricular Assist Device Support in Patients With Severe Heart Failure
Why the study?
Does LVAD support induce reverse remodeling in both the left and right ventricles compared to medical support alone in patients with severe heart failure?
Population
86 patients with severe heart failure undergoing heart transplantation
Comparison
Left ventricular assist device support for a… vs Medical support alone (without LVAD support)
Design
Cohort
Follow-up
median 46 days
Authors
Discussion
Loading...
Member takes
Implication
LVAD unloading may preferentially reverse-remodel the LV; leaves open the relative role of systemic factors in RV recovery.
Structured PICO
Does LVAD support induce reverse remodeling in both the left and right ventricles compared to medical support alone in patients with severe heart failure?
P
Population
86 patients with severe heart failure undergoing heart transplantation (53 on medical support, 33 on LVAD support)
I
Intervention
Left ventricular assist device (LVAD) support for a median of 46 days (range 8 to 360 days)
C
Comparator
Medical support alone (without LVAD support)
O
Outcome
Structural and functional characteristics of the right and left ventricles (V30, myocyte diameter, SERCA2a content, force-frequency relations)surrogate
LVAD support induces reverse remodeling primarily in the mechanically unloaded left ventricle rather than the right ventricle, highlighting the primary role of hemodynamic unloading over systemic neurohormonal factors.
Cite This Study
Barbone et al. (2001) studied this question.