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Synthesize current evidence on how oxidative stress drives neuronal death in neurodegenerative disorders and evaluate emerging redox-based therapeutics.

June 1, 2006Journal of Neurochemistry

Oxidative stress and neurodegeneration: where are we now?

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Synthesize current evidence on how oxidative stress drives neuronal death in neurodegenerative disorders and evaluate emerging redox-based therapeutics.
Reviewed mechanistic evidence linking limited endogenous antioxidant defenses in the central nervous system to chronic cellular damage.
Evaluated intertwined pathological cascades encompassing mitochondrial dysfunction, protein aggregation, inflammation, and impaired protein clearance.
The brain exhibits heightened vulnerability to oxidative stress due to insufficient native antioxidant defense systems, which fail to counter baseline and disease-accelerated damage.
Mitochondrial dysfunction, neuroinflammation, accumulation of oxidized aggregated proteins, and defective protein clearance act concurrently to drive progressive neuronal cell loss.
Targeted interventions grounded in redox biology are emerging on the therapeutic horizon for specific neurodegenerative diseases.

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Implication

Narrative review reveals intertwined oxidative and mitochondrial damage pathways in the nervous system, highlighting emerging opportunities for redox biology-based therapies.

Cite This Study

Barry Halliwell (2006) studied this question.

synapsesocial.com/papers/69daa1ba85037e71b2684337 https://doi.org/10.1111/j.1471-4159.2006.03907.x

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Implication

Narrative review reveals intertwined oxidative and mitochondrial damage pathways in the nervous system, highlighting emerging opportunities for redox biology-based therapies.

Oxidative stress and neurodegeneration: where are we now?

Key Points

Discussion

Implication

Cite This Study

Oxidative stress and neurodegeneration: where are we now?

Key Points

Discussion

Implication

Cite This Study

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