Does the loss of Yap/Taz in cardiac fibroblasts attenuate adverse remodelling and improve cardiac function after myocardial infarction?
Loss of Yap/Taz in cardiac fibroblasts attenuates adverse remodeling and improves cardiac function following myocardial infarction by modulating fibrotic and inflammatory pathways.
We demonstrate that Yap/Taz play an important role in controlling MI-induced cardiac fibrosis by modulating fibroblasts proliferation, transdifferentiation into myofibroblasts, and fibroinflammatory programme.
Mia et al. (Sun,) studied this question.