Why the study?
What is the incidence and natural history of congenital heart disease in a large prospective birth cohort?
What is the incidence and natural history of congenital heart disease in a large prospective birth cohort?
This large prospective birth cohort establishes the incidence of congenital heart disease at approximately 8 per 1000 births, with similar rates across racial groups and a high rate of spontaneous VSD closure.
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Incidence data inform prenatal counseling and planning; leaves open generalizability of VSD closure rates to other cohorts.
Mitchell et al. (1971) studied this question.
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