What question did this study set out to answer?

To identify novel molecular components required for the recruitment and assembly of Dnm1p complexes during mitochondrial fission.

October 16, 2000The Journal of Cell BiologyOpen Access

Dnm1p Gtpase-Mediated Mitochondrial Fission Is a Multi-Step Process Requiring the Novel Integral Membrane Component Fis1p

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To identify novel molecular components required for the recruitment and assembly of Dnm1p complexes during mitochondrial fission.
Conducted a genetic screen in yeast to identify components essential for mitochondrial division.
Assessed mitochondrial morphology and analyzed the localization and assembly of Dnm1p and Mdv1p (Fis2p) complexes in wild-type and mutant strains.
Identified FIS1 and FIS2 (MDV1), establishing Fis1p as a novel integral outer mitochondrial membrane protein with its N-terminus exposed to the cytoplasm.
Demonstrated that Fis1p function, but not Mdv1p function, is required for the proper assembly and distribution of Dnm1p-containing fission complexes on mitochondrial tubules.

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Implication

Genetic study demonstrates that outer membrane protein Fis1p mediates Dnm1p assembly during mitochondrial fission in yeast, indicating a multi-step division pathway.

Cite This Study

Mozdy et al. (2000) studied this question.

synapsesocial.com/papers/69dab4e4aae38ff6ad836012 https://doi.org/10.1083/jcb.151.2.367

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Implication

Genetic study demonstrates that outer membrane protein Fis1p mediates Dnm1p assembly during mitochondrial fission in yeast, indicating a multi-step division pathway.

Dnm1p Gtpase-Mediated Mitochondrial Fission Is a Multi-Step Process Requiring the Novel Integral Membrane Component Fis1p

Key Points

Discussion

Implication

Cite This Study

Dnm1p Gtpase-Mediated Mitochondrial Fission Is a Multi-Step Process Requiring the Novel Integral Membrane Component Fis1p

Key Points

Discussion

Implication

Cite This Study

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