What question did this study set out to answer?

To identify the function of the WD40 repeat protein Caf4p and define its role within the mitochondrial division machinery.

July 11, 2005The Journal of Cell BiologyOpen Access

The WD40 protein Caf4p is a component of the mitochondrial fission machinery and recruits Dnm1p to mitochondria

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To identify the function of the WD40 repeat protein Caf4p and define its role within the mitochondrial division machinery.
Examined protein-protein interactions among Caf4p, Fis1p, Mdv1p, and Dnm1p using domain-mapping experiments.
Evaluated mitochondrial morphology and Dnm1p recruitment in wild-type, mdv1Δ, and mdv1Δ caf4Δ yeast strains.
Caf4p localizes to mitochondria via Fis1p, binding Fis1p and Mdv1p via its amino-terminal region and Dnm1p via its carboxyl-terminal WD40 domain.
Yeast cells lacking Mdv1p retain residual mitochondrial fission activity that is sustained by redundant Caf4p function.
Simultaneous deletion of both MDV1 and CAF4 abolishes the recruitment of Dnm1p to mitochondrial division sites.

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Implication

Molecular study reveals Caf4p acts with Mdv1p to recruit Dnm1p during mitochondrial fission in yeast, highlighting a revised assembly model for the division apparatus.

Cite This Study

Griffin et al. (2005) studied this question.

synapsesocial.com/papers/6a1e73247f6e8bbb2368ecac https://doi.org/10.1083/jcb.200503148

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Implication

Molecular study reveals Caf4p acts with Mdv1p to recruit Dnm1p during mitochondrial fission in yeast, highlighting a revised assembly model for the division apparatus.

The WD40 protein Caf4p is a component of the mitochondrial fission machinery and recruits Dnm1p to mitochondria

Key Points

Discussion

Implication

Cite This Study

The WD40 protein Caf4p is a component of the mitochondrial fission machinery and recruits Dnm1p to mitochondria

Key Points

Discussion

Implication

Cite This Study

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