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January 1, 1994Circulation427 citations

Serial echocardiographic assessment of left ventricular geometry and function after large myocardial infarction in the rat.

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SLS E LitwinSKSarah E. KatzJMJames P. Morgan

Structured PICO

Can postinfarction LV remodeling in rats be tracked longitudinally with transthoracic echocardiography?

P
Population
Rats with large myocardial infarction
I
Intervention
Serial transthoracic echocardiography
O
Outcome
Assessment of left ventricular geometry and function (postinfarction LV remodeling)surrogate

Transthoracic echocardiography is a viable method for longitudinally tracking postinfarction left ventricular remodeling in rat models.

Abstract

Postinfarction LV remodeling in the rat is characterized by progressive cavity dilatation, inadequate hypertrophy of the surviving myocardium, the gradual development of regional contractile dysfunction in noninfarcted segments, and marked abnormalities of diastolic filling. These changes can be tracked longitudinally with transthoracic echocardiography.

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Cite This Study

Litwin et al. (1994) studied this question.

synapsesocial.com/papers/69daba11387cf706986877bdhttps://doi.org/10.1161/01.cir.89.1.345
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