What question did this study set out to answer?

To review the mechanisms driving fatty acid metabolism reprogramming in cancer cells and evaluate therapeutic strategies to target these metabolic vulnerabilities.

December 10, 2019British Journal of CancerOpen Access

Reprogramming of fatty acid metabolism in cancer

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Authors

NKNikos KoundourosCornell University GPGeorge PoulogiannisInstitute of Cancer Research

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Implication

Review uncovers mechanisms of reprogrammed fatty acid metabolism in malignant cells, highlighting therapeutic strategies targeting lipid dependencies in cancer progression.

Key Points

To review the mechanisms driving fatty acid metabolism reprogramming in cancer cells and evaluate therapeutic strategies to target these metabolic vulnerabilities.
Synthesized current literature across four key domains: de novo fatty acid synthesis versus exogenous uptake, oncogenic signaling regulation, microenvironmental remodeling in metastasis, and therapeutic targeting.
Cancer cells rewire lipid pathways to maintain energy production, membrane biogenesis, and secondary messenger signaling through coordinated changes in de novo synthesis and scavenging.
Oncogenic drivers, notably the PI3K-AKT-mTOR signaling axis, regulate fatty acid reprogramming to facilitate tumor microenvironment remodeling and metastatic progression.
Therapeutic disruption of lipid synthesis and uptake pathways presents viable targets to exploit cancer-specific metabolic dependencies and improve targeted treatment outcomes.

Cite This Study

Koundouros et al. (2019) studied this question.

synapsesocial.com/papers/69dacabb0d8d6ef495a3c2cf https://doi.org/10.1038/s41416-019-0650-z

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Implication

Review uncovers mechanisms of reprogrammed fatty acid metabolism in malignant cells, highlighting therapeutic strategies targeting lipid dependencies in cancer progression.

Reprogramming of fatty acid metabolism in cancer

Discussion

Member takes

Implication

Key Points

Cite This Study

Reprogramming of fatty acid metabolism in cancer

Discussion

Member takes

Implication

Key Points

Cite This Study

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