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Abstract Case records of 425 patients with Hodgkin's disease treated at the NIH were reviewed. Note of all biopsy-proved malignant tumors other than Hodgkin's disease was made. Cases were divided into subgroups on the basis of treatment received, and expected incidences of malignant tumors were calculated for each subgroup on the basis of age, sex, and mean follow-up period from the time of diagnosis of Hodgkin's disease. Significantly increased risks of development of second malignant tumors were found in the entire 425 patients (ratio of observed to expected, 3.5) and in the subgroups treated with both radiotherapy and chemotherapy (ratio, 3.3) and with intensive radiotherapy without intensive chemotherapy (ratio, 3.8). The greatest increase in risk was observed in 35 patients who received both intensive radiotherapy and intensive chemotherapy (ratio, 29).
Arseneau et al. (Thu,) studied this question.