Why the study?
Does mediastinal irradiation for Hodgkin's disease increase the risk of late mortality from heart disease compared to a matched general population?
Population
2,232 consecutive Hodgkin's disease patients treated from 1960 through 1991
Comparison
Hodgkin's disease therapy vs Matched general population
Design
Cohort
Follow-up
average 9.5 years
Authors
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May support cardiac surveillance in Hodgkin survivors; leaves open optimal modern radiation techniques and prevention.
Does mediastinal irradiation for Hodgkin's disease increase the risk of late mortality from heart disease compared to a matched general population?
Mediastinal irradiation for Hodgkin's disease significantly increases the long-term risk of cardiac death, highlighting the need for protective cardiac blocking and long-term cardiovascular surveillance in this population.
S. L. Hancock (1993) studied this question.
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