Key result
Treatment for Hodgkin's disease in childhood and adolescence increased the risk of death from cardiac disease compared to the general population (RR 29.6; 95% CI 16.0-49.3).
Why the study?
Does mediastinal radiation for Hodgkin's disease increase the risk of cardiac death in children and adolescents?
Cohort (n=635)
No
Does mediastinal radiation for Hodgkin's disease increase the risk of cardiac death in children and adolescents?
Effect estimate: RR 29.6 (95% CI 16.0-49.3)
Mediastinal radiation of 40 to 45 Gy for Hodgkin's disease in children and adolescents significantly increases the risk of death from cardiac diseases, including acute myocardial infarction.
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Survivors warrant enhanced cardiac surveillance; leaves open optimal radiation dosing in prospective cohorts.
Hancock et al. (1993) conducted a cohort in Hodgkin's disease (n=635). Mediastinal radiation and/or chemotherapy vs. Age-, sex-, and race-matched general population was evaluated on Death from cardiac disease (RR 29.6, 95% CI 16.0-49.3). Treatment for Hodgkin's disease in childhood and adolescence increased the risk of death from cardiac disease compared to the general population (RR 29.6; 95% CI 16.0-49.3).
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