Key result
Among pediatric Hodgkin's lymphoma survivors, adolescent age at diagnosis was associated with a significantly higher risk of cardiac-specific mortality (HR 3.05; p=0.005).
Cohort (n=6,552)
Yes
Hazard Ratio: 3.05
p-value: p=0.005
Pediatric and adolescent survivors of Hodgkin's lymphoma face a long-term risk of cardiac mortality, particularly males and those diagnosed in adolescence, though rates have declined in recent decades.
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May inform cardiac surveillance in high-risk pediatric HL survivors; leaves open prospective validation of risk groups.
Amini et al. (2016) conducted a cohort in Pediatric Hodgkin's lymphoma (n=6,552). Adolescent age at diagnosis (13-21 years) vs. Younger age at diagnosis was evaluated on Cardiac mortality (HR 3.05, p=0.005). Among pediatric Hodgkin's lymphoma survivors, adolescent age at diagnosis was associated with a significantly higher risk of cardiac-specific mortality (HR 3.05; p=0.005).
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