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June 15, 2021Hepatology ResearchOpen Access

MAFLD better predicts the progression of atherosclerotic cardiovascular risk than NAFLD: Generalized estimating equation approach

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Key Points

To determine whether metabolic dysfunction-associated fatty liver disease (MAFLD) predicts the progression of atherosclerotic cardiovascular disease (ASCVD) risk more effectively than non-alcoholic fatty liver disease (NAFLD).
Applied a generalized estimating equation (GEE) approach to model the progression of atherosclerotic cardiovascular disease risk.
Compared risk trajectories between MAFLD and NAFLD classifications, examining the relative contributions of metabolic dysfunction and moderate alcohol consumption.
MAFLD identified patients experiencing a worsening of atherosclerotic cardiovascular disease risk better than NAFLD.
The diagnostic superiority of MAFLD was driven by the inclusion of metabolic dysfunction rather than the presence of moderate alcohol consumption.

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Implication

Demonstrates that MAFLD better predicts worsening atherosclerotic cardiovascular risk than NAFLD, indicating that metabolic dysfunction drives cardiovascular progression.

Abstract

The GEE approach demonstrates that MAFLD better identifies patients with worsening of ASCVD risk than NAFLD. Moreover, the superiority of MAFLD over NAFLD was due to the presence of metabolic dysfunction rather than moderate alcohol consumption.

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Cite This Study

Tsutsumi et al. (2021) studied this question.

synapsesocial.com/papers/69dad3d74e9a02dbaa684a0f https://doi.org/10.1111/hepr.13685

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