Why the study?
Does aptamer-based proteomic profiling reveal novel candidate biomarkers and pathways in cardiovascular disease?
Does aptamer-based proteomic profiling reveal novel candidate biomarkers and pathways in cardiovascular disease?
Aptamer-based proteomic profiling offers a high-sensitivity and high-precision approach to discovering novel cardiovascular biomarkers.
Facilitates discovery of low-abundance cardiovascular biomarkers; leaves open clinical translation pending validation.
Our results highlight an emerging proteomics tool capable of profiling >1000 low-abundance analytes with high sensitivity and high precision, applicable both to well-phenotyped perturbational studies and large human cohorts, as well.
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Ngo et al. (2016) studied this question.
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