Comorbidities complicating heart failure: changes over the last 15 years

Figures

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  Fig. 1. Distribution of comorbidities in different age categories in A) 2002-HF cohort and B) 2017-HF cohort. Increasing color intensity represents higher number of comorbidities as shown in the legend

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  Fig. 2. Kaplan-Meier curve for the combined endpoint (e.g. HF hospitalization and all-cause mortality), stratified by 2002- and 2017-HF cohort

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  Fig. 3. Relationship between number of comorbidities and the estimated hazard ratio of the combined endpoint (e.g. HF hospitalization and all-cause mortality) in patients from the 2002-HF cohort (orange) and the 2017-HF cohort (dark green). Data is adjusted for the clinical risk model: age, sex, LVEF, sodium, log(NT-proBNP) and eGFR. The histogram represents the percentage of patients with that specific number of comorbidities

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  Fig. 4. Forest plot showing the hazard ratio [95% CI] associated with individual comorbidities to the primary combined endpoint. Data is adjusted for the clinical risk model: age, sex, LVEF, sodium, log(NT-proBNP) and eGFR. p-values for interaction refer to interaction term between 2002- and 2017-HF cohort and respective comorbidity. Bold values denote statistical significance at the p < 0.10 level for interaction terms and p < 0.05 level for all other analyses