What question did this study set out to answer?

Determine the host, viral, and environmental factors that govern viral diversity and predict cross-species transmission of mammalian viruses into humans.

June 20, 2017NatureOpen Access

Host and viral traits predict zoonotic spillover from mammals

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Authors

KOKevin J. OlivalEcoHealth Alliance PHParviez R. HosseiniEcoHealth Alliance CZCarlos Zambrana‐TorrelioGeorge Mason University

Discussion

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Implication

Comparative analysis demonstrates host and viral traits predict zoonotic spillover risk in wild mammals, highlighting priority targets for pandemic surveillance.

Key Points

Determine the host, viral, and environmental factors that govern viral diversity and predict cross-species transmission of mammalian viruses into humans.
Conducted a comprehensive comparative analysis of mammalian host-virus relationships while controlling for confounding variations in research effort.
Modeled predictors of zoonotic virus proportions using host taxonomy, phylogenetic distance to humans, human population overlap within host ranges, and viral traits such as phylogenetic host breadth.
Host phylogenetic relatedness to humans, host taxonomy, and human population density within a species range significantly predict the proportion of zoonotic viruses carried by a mammalian species.
Bats host a significantly higher proportion of zoonotic viruses than all other mammalian orders.
Phylogenetic host breadth and distinct viral traits reliably predict zoonotic capacity, establishing a predictive framework to assess the spillover risk of novel mammalian viruses.

Cite This Study

Olival et al. (2017) studied this question.

synapsesocial.com/papers/69dadad71e19c8ae088359ca https://doi.org/10.1038/nature22975

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June 20, 2017NatureOpen Access

Host and viral traits predict zoonotic spillover from mammals

View Full Paper

Ask AI

Bookmark

Authors

KOKevin J. OlivalEcoHealth Alliance PHParviez R. HosseiniEcoHealth Alliance CZCarlos Zambrana‐TorrelioGeorge Mason University

Discussion

Member takes

Implication

Comparative analysis demonstrates host and viral traits predict zoonotic spillover risk in wild mammals, highlighting priority targets for pandemic surveillance.

Key Points

Determine the host, viral, and environmental factors that govern viral diversity and predict cross-species transmission of mammalian viruses into humans.
Conducted a comprehensive comparative analysis of mammalian host-virus relationships while controlling for confounding variations in research effort.
Modeled predictors of zoonotic virus proportions using host taxonomy, phylogenetic distance to humans, human population overlap within host ranges, and viral traits such as phylogenetic host breadth.
Host phylogenetic relatedness to humans, host taxonomy, and human population density within a species range significantly predict the proportion of zoonotic viruses carried by a mammalian species.
Bats host a significantly higher proportion of zoonotic viruses than all other mammalian orders.
Phylogenetic host breadth and distinct viral traits reliably predict zoonotic capacity, establishing a predictive framework to assess the spillover risk of novel mammalian viruses.

Cite This Study

Olival et al. (2017) studied this question.

synapsesocial.com/papers/69dadad71e19c8ae088359ca https://doi.org/10.1038/nature22975

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