Population
Preclinical model (coexpressed alpha and beta subunits of the high conductance Ca2+-activated K+ channel)
Comparison
Ala scanning mutagenesis along the extracellular… vs Native beta subunit or alpha subunit expressed…
Design
Preclinical
Authors
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No immediate implications for cardiovascular care; extends molecular mapping of BK channel beta subunit.
Four specific residues and two disulfide bridges in the extracellular loop of the maxi-K channel beta subunit are critical for inducing a conformation in the alpha subunit that allows high affinity charybdotoxin binding.
Hanner et al. (1998) studied this question.
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