Key result
In human coronary artery smooth muscle cells, most maxi KCa channels are composed of alpha and beta subunits, resulting in higher Ca2+ sensitivity and potentiation by DHS-I.
Most maxi KCa channels in human coronary smooth muscle cells are composed of alpha and beta subunits, conferring high Ca2+ sensitivity that likely regulates coronary tone.
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Demonstration of alpha-beta coupling in native human coronary myocytes; extends heterologous studies but leaves clinical relevance open.
Tanaka et al. (1997) studied Human coronary smooth muscle cells. alpha and beta subunit coupling vs. alpha subunit alone was evaluated on apparent Ca2+ sensitivity (V1/2) and activation by DHS-I. In human coronary artery smooth muscle cells, most maxi KCa channels are composed of alpha and beta subunits, resulting in higher Ca2+ sensitivity and potentiation by DHS-I.
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