July 24, 2004The Journal of PhysiologyOpen Access

Functional and molecular evidence of MaxiK channel β1 subunit decrease with coronary artery ageing in the rat

View Full Paper

Ask AI

Bookmark

Population

Coronary myocytes from young and old F344 rats

Comparison

Ageing (old rats) vs Young rats

Design

Preclinical

Authors

KNKazuhide NishimaruYamagata University MEMansoureh EghbaliUniversity of California, Los Angeles RLRong LüJuntendo University

Discussion

Member takes

Implication

May contribute to age-related coronary flow changes; hypothesis-generating for MaxiK transcript regulation in human aging.

Structured PICO

Population

Coronary myocytes from young and old F344 rats

Intervention

Ageing (old rats)

Comparator

Young rats

Outcome

Functional and pharmacological characteristics of MaxiK channels, and alpha and beta1 transcript levelssurrogate

Age-related reduction in MaxiK channels in coronary arteries involves a parallel decrease in alpha and beta1 functional expression via transcript downregulation, potentially contributing to altered coronary flow regulation in the elderly.

Cite This Study

Nishimaru et al. (2004) studied this question.

synapsesocial.com/papers/6a82bf5cc19603ede244032a https://doi.org/10.1113/jphysiol.2004.068676

View Full Paper

Ask AI

Bookmark

Functional and molecular evidence of MaxiK channel β1 subunit decrease with coronary artery ageing in the rat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Functional and molecular evidence of MaxiK channel β1 subunit decrease with coronary artery ageing in the rat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider