Key result
Aging significantly reduced MaxiK channel density in coronary arteries from 52 to 18 channels/pF in rats and by approximately 80% in older humans, decreasing vasodilating capacity.
Authors
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May explain age-related coronary vasomotor impairment; hypothesis-generating and should not yet change practice.
Effect estimate: 65% reduction
Absolute Event Rate: 18% vs 52%
Marijic et al. (2001) studied Coronary artery aging. Aging vs. Younger age was evaluated on MaxiK channel density (65% reduction). Aging significantly reduced MaxiK channel density in coronary arteries from 52 to 18 channels/pF in rats and by approximately 80% in older humans, decreasing vasodilating capacity.
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