August 28, 2014Circulation
Ubiquitin-Like Protein ISG15 (Interferon-Stimulated Gene of 15 kDa) in Host Defense Against Heart Failure in a Mouse Model of Virus-Induced Cardiomyopathy
Population
Mouse model of virus-induced cardiomyopathy
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Supports ISG15 modulation as a target in viral cardiomyopathy models; leaves open translation to human disease.
Structured PICO
P
Population
Mouse model of virus-induced cardiomyopathy
I
Intervention
ISG15 conjugation system
O
Outcome
Inflammatory cardiomyopathy, heart failure, and death
Interference with the ISG15 system might be a novel therapeutic approach in viral cardiomyopathy.
Cite This Study
Rahnefeld et al. (2014) studied this question.