Inhibition of oxidative stress-induced epithelial-mesenchymal transition in retinal pigment epithelial cells of age-related macular degeneration model by suppressing ERK activation

Ya-Chi Yang; Ya-Chi Yang; Yueh Chien; Aliaksandr A. Yarmishyn; Lee-Yieng Lim; Hao-Yu Tsai; Wen‐Chuan Kuo; Ping‐Hsing Tsai; Sheng-Hsien Yang; S.D. Hong; Shih‐Jen Chen; De‐Kuang Hwang; Yi‐Ping Yang; Yi‐Ping Yang; Shih‐Hwa Chiou

doi:10.1016/j.jare.2023.06.004

June 16, 2023Journal of Advanced ResearchOpen Access

Inhibition of oxidative stress-induced epithelial-mesenchymal transition in retinal pigment epithelial cells of age-related macular degeneration model by suppressing ERK activation

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Abstract

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ERK is a crucial regulator of multiple NaIO₃-induced signaling pathways that coordinate EMT program in RPE cells. Inhibition of ERK may be a potential therapeutic strategy for the treatment of AMD.

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Yang et al. (2023) studied this question.

synapsesocial.com/papers/69db23374a1e15904c837057 https://doi.org/10.1016/j.jare.2023.06.004

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Inhibition of oxidative stress-induced epithelial-mesenchymal transition in retinal pigment epithelial cells of age-related macular degeneration model by suppressing ERK activation

Abstract

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Inhibition of oxidative stress-induced epithelial-mesenchymal transition in retinal pigment epithelial cells of age-related macular degeneration model by suppressing ERK activation

Abstract

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