Correction: Impact of diets high in trans-fatty acids on cardiovascular diseases in adults aged 55 and older: insights from the Global Burden of Disease 2021 data

Q: What does this research mean for the field?

Between 1990 and 2021, the global cardiovascular disease burden attributable to high trans-fatty acid intake in adults aged 55 and older declined significantly, although substantial disparities persist with higher burdens remaining in low- and middle-SDI regions. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

Jishi Ye; Yu Liu; Juan Ren; Ruolan Wu; Jingli Chen; Rong Xiang; Yonghong Jia

doi:10.3389/fnut.2026.1824926

April 8, 2026Frontiers in NutritionOpen Access

Correction: Impact of diets high in trans-fatty acids on cardiovascular diseases in adults aged 55 and older: insights from the Global Burden of Disease 2021 data

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Why the study?

A comprehensive analysis focusing on the CVD mortality and DALY burden attributable to high trans-fatty acid intake among adults aged 55 and older was lacking.

Does a diet high in trans-fatty acids impact cardiovascular disease mortality and DALYs in adults aged 55 and older?

Key Points

The study aims to analyze the trends in cardiovascular disease (CVD) mortality and disability-adjusted life years (DALYs) associated with high trans-fatty acid intake for adults aged 55 and older from 1990 to 2021.
Utilized Global Burden of Disease (GBD) 2021 data and age-period-cohort (APC) modeling.
Evaluated age-standardized mortality rates (ASMR) and disability-adjusted life year rates (ASDR).
Assessed trends using the estimated annual percentage change (EAPC) and socio-demographic index (SDI).
Performed local drift analysis and Bayesian Age-Period-Cohort (BAPC) modeling.
Analyzed sex-specific and age-specific burden across different socioeconomic and geographic strata.
CVD deaths due to high TFA consumption decreased from 104 million in 1990 to 71.32 million in 2021, marking a 32% reduction.
Age-standardized mortality rates declined from 15.5 to 4.8 per 100,000, reflecting a 69% decrease.
Significant reductions were observed in high-SDI regions, with a 91% decrease in deaths.
CVD burden remains a challenge in low-SDI regions, despite an overall global decline.
There are notable sex differences in CVD burden, with males experiencing a higher burden than females, especially in low-SDI regions.

Structured PICO

Does a diet high in trans-fatty acids impact cardiovascular disease mortality and DALYs in adults aged 55 and older?

P

Population

Adults aged 55 years and older across 204 countries and territories from the Global Burden of Disease 2021 data

I

Intervention

Diet high in trans-fatty acids (TFA)

O

Outcome

Cardiovascular disease mortality and disability-adjusted life years (DALYs)hard clinical

The global burden of cardiovascular disease attributable to high trans-fatty acid intake in older adults has significantly decreased from 1990 to 2021, though regional disparities persist.

Implication

TFA reduction should remain a priority for adults ≥55 in low-SDI regions; reinforces value of regulatory policies in lowering CVD mortality.

Discussion

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Cite This Study

Ye et al. (2026) studied this question.

synapsesocial.com/papers/69db361c4fe01fead37c453c https://doi.org/10.3389/fnut.2026.1824926

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Correction: Impact of diets high in trans-fatty acids on cardiovascular diseases in adults aged 55 and older: insights from the Global Burden of Disease 2021 data

Key Points

Structured PICO

Implication

Discussion

Cite This Study

Correction: Impact of diets high in trans-fatty acids on cardiovascular diseases in adults aged 55 and older: insights from the Global Burden of Disease 2021 data

Key Points

Structured PICO

Implication

Discussion

Cite This Study

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