What question did this study set out to answer?

The study aims to assess the performance of dried blood spot point-of-care testing for diagnosing sickle cell disease in newborns across multiple African countries.

April 12, 2026HemoglobinOpen Access

SickleInAfrica Consortium: A Seven-Country Study Evaluating the Performance of Dried Blood Spot Point-of-Care Testing in Newborn Screening for Sickle Cell Disease

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Authors

ONObiageli NnoduUniversity of Abuja WMWilson MupfururirwaThe Coordinating Center SKSarah Kiguli

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Implication

Seven-country study evaluates diagnostic accuracy of dried blood spot testing for sickle cell disease in newborns, suggesting improvement in screening access.

Key Points

The study aims to assess the performance of dried blood spot point-of-care testing for diagnosing sickle cell disease in newborns across multiple African countries.
Evaluated dried blood spot point-of-care testing using HemoTypeSC across 705 newborns.
Compared DBS-POCT with standard point-of-care tests and reference laboratory testing.
Conducted the study in seven countries of the SickleInAfrica Consortium.
DBS-POCT showed high sensitivity and specificity for HbAA and HbAS.
Moderate sensitivity was observed for HbSS, while sensitivity for HbAC was lower.
In many cases, DBS-POCT outperformed standard POCT, particularly in identifying different SCD subtypes.

Cite This Study

Nnodu et al. (2026) studied this question.

synapsesocial.com/papers/69db36a04fe01fead37c4a57 https://doi.org/10.1080/03630269.2026.2630709

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Implication

Seven-country study evaluates diagnostic accuracy of dried blood spot testing for sickle cell disease in newborns, suggesting improvement in screening access.

SickleInAfrica Consortium: A Seven-Country Study Evaluating the Performance of Dried Blood Spot Point-of-Care Testing in Newborn Screening for Sickle Cell Disease

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Implication

Key Points

Cite This Study

SickleInAfrica Consortium: A Seven-Country Study Evaluating the Performance of Dried Blood Spot Point-of-Care Testing in Newborn Screening for Sickle Cell Disease

Discussion

Member takes

Implication

Key Points

Cite This Study

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