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The research aims to identify a novel allele variant of HLA-B through sequencing techniques.

April 12, 2026HLA

Identification of the Novel HLA‐B*58:162 Allele by Next‐Generation Sequencing

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The research aims to identify a novel allele variant of HLA-B through sequencing techniques.
Utilized next-generation sequencing for genetic analysis
Focused on HLA-B alleles and nucleotide variations
Analyzed nucleotide changes specifically at codon 66 in exon 2
Discovered HLA-B*58:162 as a new allele variant
Identified a nucleotide change from HLA-B*58:01:01:01 at codon 66
Confirmed the significance of the nucleotide change in the allele's identification

Identifies HLA-B*58:162 allele through next-generation sequencing, suggesting its genetic significance.

HLA‐B*58:162 differs from HLA‐B*58:01:01:01 by one non‐synonymous nucleotide change in codon 66 in exon 2.

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Shi et al. (2026) studied this question.

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Identifies HLA-B*58:162 allele through next-generation sequencing, suggesting its genetic significance.

HLA‐B*58:162 differs from HLA‐B*58:01:01:01 by one non‐synonymous nucleotide change in codon 66 in exon 2.