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April 1, 2026HLA

Identification of the Novel HLA‐B*40:594N Allele by Next‐Generation Sequencing

Jianing Yuan Bin Xi Zheng Shi Mingrui Huo

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Key Points

To identify and characterize the novel HLA-B*40:594N allele through sequencing techniques.
Utilized next-generation sequencing to analyze genetic material.
Focused on the HLA-B region for allele identification.
Compared the allele with HLA-B*40:02:01:01 to detect differences.
Identified a single nucleotide substitution in codon 164.
Characterized the novel HLA-B*40:594N allele as distinct from HLA-B*40:02:01:01.

Implication

This analysis identifies the novel HLA-B*40:594N allele, indicating genetic variation in the HLA-B region.

Abstract

The HLA‐B*40:594N allele differs from HLA‐B*40:02:01:01 by one nucleotide substitution in codon 164 in exon 3.

Discussion

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Cite This Study

Yuan et al. (2026) studied this question.

synapsesocial.com/papers/69e07e3b2f7e8953b7cbf444 https://doi.org/10.1111/tan.70718

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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