October 16, 2025HLA

Characterisation of the Novel HLA‐B*40:01:02:68Q Allele by Sequencing‐Based Typing

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HLA-B*40:01:02:68Q allele differs from a related allele by a single nucleotide change.
This nucleotide substitution occurs at the splice site between intron 2 and exon 3.
Sequencing-based typing reveals the importance of specific nucleotide changes in allele characterization.
Understanding these variations can enhance insights into genetic diversity and immune response.

Implication

Analysis shows nucleotide substitution in intron affecting exon 3 in HLA-B*40:01:02:68Q, suggesting genetic variations.

HLA‐B*40:01:02:68Q differs from HLA‐B*40:01:02:01 by one nucleotide substitution in intron 2 at the splice site with exon 3.

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Pajot et al. (2025) studied this question.

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Analysis shows nucleotide substitution in intron affecting exon 3 in HLA-B*40:01:02:68Q, suggesting genetic variations.

HLA‐B*40:01:02:68Q differs from HLA‐B*40:01:02:01 by one nucleotide substitution in intron 2 at the splice site with exon 3.