Association between the IGFBP-3 rs2854744 polymorphism and cancer risk: a meta-analysis

Recently, the association of IGFBP-3 polymorphism and cancer risk has attracted many attentions. Previous studies have shown that IGFBP-3 rs2854744 was associated with cancer, but the results were conflicting. We performed a meta-analysis including 33 studies with 24,688 cases and 28,972 controls to seek the association among them. A significant increase of cancer risk was found between the IGFBP-3 rs2854744 Polymorphism and cancer risk in Recessive Model (CC vs. AC/AA: OR = 1.097, 95%CI: 1.020, 1.180, P < 0.05). While in subgroup analysis, A same increase of breast cancer risk also have been shown in our study in Recessive Model (CC vs. AC/AA: OR = 1.126, 95%CI: 1.007, 1.260, P < 0.05). The results of our meta-analysis concluded that the IGFBP-3 rs2854744 polymorphism was closely related with the increase of cancer risk while further large size case–control studies are required.