In vitro analysis shows rs1077773 enhances AHR activity in immune cells, suggesting new therapeutic strategies for IBD.
This work demonstrates that rs1077773 enhances AHR activity and modulates epithelial and immune cell function in vitro. Further mechanistic understanding of this locus and its correlates could improve our understanding of the molecular mechanisms of IBD susceptibility and may lead to novel personalized therapeutic approaches in IBD.
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King et al. (2026) studied this question.
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