What does this research mean for the field?

Most barriers to increasing clozapine prescribing in treatment-resistant schizophrenia are structural and beyond the influence of individual prescribers, necessitating systemic interventions such as reduced administrative burden, standardized training, and dedicated clinics. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This review aims to identify barriers and facilitators affecting clozapine prescribing by clinicians for treatment-resistant schizophrenia.

April 12, 2026European Journal of Clinical PharmacologyOpen Access

Clozapine prescribing in treatment-resistant schizophrenia – an updated systematic literature review of barriers and facilitators among clinicians

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Authors

SNSiobhán NolanUniversity College Cork LSLaura J. SahmNational University of Ireland IFIta FitzgeraldAston University

Discussion

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Implication

A systematic review highlights barriers and facilitators for clinicians prescribing clozapine in treatment-resistant schizophrenia, indicating areas for improvement.

Key Points

This review aims to identify barriers and facilitators affecting clozapine prescribing by clinicians for treatment-resistant schizophrenia.
Conducted a systematic review according to PRISMA guidelines.
Searched databases including PubMed, Embase, CINAHL, and PsycINFO until July 2025.
Synthesized results qualitatively from fifteen included studies.
Identified clinician-related barriers such as low knowledge and confidence in managing clozapine.
Noted patient-related concerns about adherence to treatment and monitoring requirements.
Highlighted institutional barriers like lack of systems for clozapine initiation and shared care.
Found facilitators including improved clinician education and access to dedicated clozapine clinics.

Cite This Study

Nolan et al. (2026) studied this question.

synapsesocial.com/papers/69db383b4fe01fead37c6696 https://doi.org/10.1007/s00228-026-04046-2

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Implication

A systematic review highlights barriers and facilitators for clinicians prescribing clozapine in treatment-resistant schizophrenia, indicating areas for improvement.

Clozapine prescribing in treatment-resistant schizophrenia – an updated systematic literature review of barriers and facilitators among clinicians

Discussion

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Implication

Key Points

Cite This Study

Clozapine prescribing in treatment-resistant schizophrenia – an updated systematic literature review of barriers and facilitators among clinicians

Discussion

Member takes

Implication

Key Points

Cite This Study

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