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July 22, 2026Australian & New Zealand Journal of PsychiatryOpen Access

Management of clozapine-resistant schizophrenia

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Authors

JLJohn LallyUniversity College DublinSGSiobhan GeeKing's College LondonCHCaroline HynesUniversity College Dublin

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Implication

Perspective article outlines evidence-informed strategies for managing clozapine-resistant schizophrenia, suggesting the need for systematic assessment and individualised treatment plans.

Key Points

  • This article aims to provide evidence-based recommendations for managing clozapine-resistant schizophrenia. It highlights the need for proper assessment to optimize treatment outcomes.
  • Summarized practical recommendations for clinicians on the management of clozapine-resistant schizophrenia.
  • Discussed the systematic assessment of individuals showing inadequate response to clozapine, focusing on various factors.
  • Emphasized therapeutic drug monitoring and individualised adjustment of plasma clozapine concentrations.
  • Early initiation of clozapine in treatment-resistant schizophrenia is linked to better outcomes.
  • No augmentation strategy has consistently shown efficacy in treating clozapine-resistant schizophrenia.
  • Future research should focus on placebo-controlled trials to improve treatment guidelines.

Cite This Study

Lally et al. (2026) studied this question.

synapsesocial.com/papers/6a605e7c4163e025518d842ehttps://doi.org/10.1177/00048674261462755
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Beyond clozapine – what options do we have in clozapine resistant schizophrenia?2025
  2. 2Clozapine for the treatment of resistant psychosis – CLOZAPINE UNIT2025
  3. 3Polypharmacy to Clozapine Monotherapy in Treatment-Resistant Schizophrenia: A Case Report and Review of the Literature2024
  4. 4Clozapine response in patients with treatment-resistant schizophrenia: a preliminary report2025
  5. 5Clozapine prescribing in treatment-resistant schizophrenia – an updated systematic literature review of barriers and facilitators among clinicians2026 · 1 citations