Resveratrol inhibits renal ischemia and reperfusion injury in diabetes via reducing oxidative stress, inflammation, and apoptosis

Daojing Gong; Xiaobo Chen; Ziqiang Dong; Huan Chen; Ziyi Liu

doi:10.1080/0886022x.2026.2652103

April 9, 2026Renal FailureOpen Access

Resveratrol inhibits renal ischemia and reperfusion injury in diabetes via reducing oxidative stress, inflammation, and apoptosis

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Key Points

This research aims to investigate how resveratrol can reduce renal injury caused by ischemia and reperfusion in diabetic conditions.
Evaluated the effects of resveratrol in a diabetic model of renal ischemia/reperfusion injury
Assessed oxidative stress levels and inflammatory markers
Analyzed signaling pathways including Nrf2/HO-1 and TLR4/NF-κB
Resveratrol significantly reduced signs of kidney injury during ischemia/reperfusion
It lowered oxidative stress and inflammatory responses
The study highlighted enhanced Nrf2/HO-1 signaling and reduced TLR4/NF-κB activity.

Implication

Experimental findings demonstrate that resveratrol reduces renal injury in diabetes, indicating a potential therapeutic approach.

Abstract

These findings indicate that RSV could attenuate renal I/R injury in diabetes, possibly by enhancing Nrf2/HO-1 signaling and suppressing the TLR4/NF-κB pathway.

Discussion

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Cite This Study

Gong et al. (2026) studied this question.

synapsesocial.com/papers/69db38534fe01fead37c697b https://doi.org/10.1080/0886022x.2026.2652103

View Full Paper

Ask AI

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Resveratrol inhibits renal ischemia and reperfusion injury in diabetes via reducing oxidative stress, inflammation, and apoptosis

Key Points

Implication

Abstract

Discussion

Cite This Study

Resveratrol inhibits renal ischemia and reperfusion injury in diabetes via reducing oxidative stress, inflammation, and apoptosis

Key Points

Implication

Abstract

Discussion

Cite This Study

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