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November 22, 2017Experimental and Therapeutic MedicineOpen Access

Protective effects of resveratrol improve cardiovascular function in rats with diabetes

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Key result

Resveratrol improves cardiovascular function in diabetic rats with MI via eNOS, VEGF, and p38 MAPK.

  • P<0.01
  • n=46

Why the study?

The protective effect of resveratrol on cardiovascular function in rats with diabetes-related myocardial infarction was evaluated.

Does resveratrol improve cardiovascular function in rats with diabetes-related myocardial infarction?

Population

Rats with diabetes-related myocardial infarction

Comparison

Resveratrol treatment vs no treatment

Design

Preclinical experimental study

Authors

FYFu-Qin YanXSXiaomeng SunCXChun Xu

Discussion

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Member takes

Overview

Resveratrol may improve CV function in diabetic rat models; leaves open clinical translation to humans.

Structured PICO

Does resveratrol improve cardiovascular function in rats with diabetes-related myocardial infarction?

P
Population
46 male Sprague Dawley rats (10-11 weeks old) with streptozocin-induced diabetes-related myocardial infarction, treated for 4 weeks.
I
Intervention
Resveratrol
O
Outcome
Cardiovascular function, metabolic parameters (blood glucose, body weight, plasma triglycerides, total plasma insulin), heart rate, AST/ALT ratio, inflammation, oxidative stress (malondialdehyde), and protein expression (eNOS, VEGF, p-p38)surrogate

Main Result

p-value: p=<0.01

Resveratrol improves cardiovascular function and metabolic parameters in a rat model of diabetes-related myocardial infarction by modulating eNOS, VEGF, and p38 pathways.

Cite This Study

Yan et al. (2017) studied Diabetes-related myocardial infarction (n=46). Resveratrol vs. Normal saline was evaluated on Blood glucose, plasma triglyceride levels, heart rate, and AST/ALT ratio (p=<0.01). Resveratrol significantly reduced blood glucose, plasma triglycerides, and heart rate, and improved cardiovascular function via modulation of eNOS, VEGF, and p38 MAPK in rats with diabetes-related myocardial infarction.

synapsesocial.com/papers/6aa8f6ac7cd5a4625c5d495dhttps://doi.org/10.3892/etm.2017.5537
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