Key result
Oral resveratrol improved cardiac function by increasing the left ventricular diastolic peak filling rate in type 2 diabetic mice through the inhibition of oxidative and nitrative stress.
Why the study?
Does resveratrol improve left ventricular diastolic relaxation in a mouse model of type 2 diabetes?
Does resveratrol improve left ventricular diastolic relaxation in a mouse model of type 2 diabetes?
Resveratrol improves left ventricular diastolic relaxation in a type 2 diabetes mouse model by inhibiting oxidative and nitrative stress pathways.
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Resveratrol effects remain preclinical; extends animal data on diabetic cardiomyopathy but leaves human translation open.
Zhang et al. (2010) studied Type 2 diabetes-induced cardiac dysfunction. Resveratrol vs. Untreated control/diabetic mice was evaluated on Left ventricular diastolic peak filling rate and oxidative/nitrative stress markers. Oral resveratrol improved cardiac function by increasing the left ventricular diastolic peak filling rate in type 2 diabetic mice through the inhibition of oxidative and nitrative stress.
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