Key result
Resveratrol attenuated cardiac dysfunction, hypertrophy, and fibrosis in diabetic mice by increasing Nrf2 expression and transcriptional activity.
Why the study?
Does resveratrol prevent diabetic cardiomyopathy in a mouse model of Type 1 diabetes mellitus?
Population
FVB mice with Type 1 diabetes mellitus induced by streptozotocin, and age-matched controls
Comparison
Resveratrol 10 mg/kg per day for 1 month vs No resveratrol
Design
Preclinical
Follow-up
6 months
Authors
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Hypothesis-generating in diabetic mice; leaves open clinical translation of Nrf2 activation for human diabetic cardiomyopathy.
Does resveratrol prevent diabetic cardiomyopathy in a mouse model of Type 1 diabetes mellitus?
Resveratrol prevents diabetic cardiomyopathy in a Type 1 diabetes mouse model by reducing oxidative stress and fibrosis via the Nrf2 pathway.
Wang et al. (2018) studied Diabetic cardiomyopathy. Resveratrol vs. Control (DM without resveratrol, and non-DM controls) was evaluated on Cardiac function, blood pressure, oxidative damage, and cardiac fibrosis. Resveratrol attenuated cardiac dysfunction, hypertrophy, and fibrosis in diabetic mice by increasing Nrf2 expression and transcriptional activity.
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