Why the study?
Do individuals with Down syndrome exhibit altered blood pressure and heart rate responses to sympathoexcitation compared to controls?
Population
24 subjects (12 with Down syndrome without congenital heart disease, and 12 without Down syndrome)
Comparison
Sympathoexcitation via maximal treadmill… vs Subjects without Down syndrome undergoing the…
Design
Case-control
Authors
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Supports autonomic dysfunction in Down syndrome that may underlie chronotropic incompetence; hypothesis-generating and requires prospective confirmation.
Do individuals with Down syndrome exhibit altered blood pressure and heart rate responses to sympathoexcitation compared to controls?
Individuals with Down syndrome exhibit reduced heart rate and blood pressure responses to sympathoexcitation, suggesting autonomic dysfunction that may explain chronotropic incompetence.
Fernhall et al. (2003) studied this question.
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