Effects of the orexin receptor 2 agonist danavorexton on emergence from general anaesthesia and opioid-induced sedation, respiratory depression, and analgesia in rats and monkeys

Motohisa Suzuki; Eri Shiraishi; James J. Cronican; Haruhide Kimura

doi:10.1016/j.bja.2023.12.032

February 1, 2024British Journal of AnaesthesiaOpen Access

Effects of the orexin receptor 2 agonist danavorexton on emergence from general anaesthesia and opioid-induced sedation, respiratory depression, and analgesia in rats and monkeys

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Key Points

To determine whether the orexin receptor 2 agonist danavorexton accelerates emergence from general anaesthesia and counteracts fentanyl-induced sedation and respiratory depression while maintaining analgesia.
Conducted preclinical in vivo experiments using rat and monkey animal models.
Assessed emergence timelines from general anaesthesia alongside sedation, respiratory rate, and analgesic responses following fentanyl and danavorexton administration.
Danavorexton enhanced emergence from general anaesthesia and promoted clearance of fentanyl-induced sedation.
Danavorexton successfully antagonized fentanyl-induced respiratory depression without reducing or compromising fentanyl-mediated analgesia.

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Implication

Preclinical study demonstrates danavorexton reverses sedation and respiratory depression in rats and monkeys, suggesting safer post-anaesthesia opioid use.

Abstract

Danavorexton promoted recovery from anaesthesia and fentanyl-induced sedation, and antagonised fentanyl-induced respiratory depression without compromising fentanyl analgesia.

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Cite This Study

Suzuki et al. (2024) studied this question.

synapsesocial.com/papers/69db70c374ec163421835c76 https://doi.org/10.1016/j.bja.2023.12.032

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Effects of the orexin receptor 2 agonist danavorexton on emergence from general anaesthesia and opioid-induced sedation, respiratory depression, and analgesia in rats and monkeys

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Effects of the orexin receptor 2 agonist danavorexton on emergence from general anaesthesia and opioid-induced sedation, respiratory depression, and analgesia in rats and monkeys

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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