Are distinct plasma metabolomic profiles associated with RV dilation, mortality, and disease severity in patients with Pulmonary Arterial Hypertension?
Polyamine, histidine, and sphingomyelin metabolic pathways represent promising biomarker candidates for identifying PAH patients at high risk for poor outcomes such as RV dilation and mortality.
Distinct plasma metabolomic profiles are associated with RV dilation, mortality, and measures of disease severity in PAH. Polyamine, histidine, and sphingomyelin metabolic pathways represent promising candidates for identifying patients at high risk for poor outcomes and investigation into their roles as markers or mediators of disease progression and RV adaptation.
Pi et al. (Wed,) studied this question.