Meta-analysis reveals individualized PEEP titration reduces postoperative pulmonary complications during one-lung ventilation, highlighting enhanced respiratory protection over fixed settings.
Compared with fixed PEEP, individualized PEEP titration by lung compliance is associated with a reduced risk of postoperative pulmonary complications during OLV, especially in PEEP titration by dynamic compliance or stepwise decremental strategy. It improves respiratory mechanics and oxygenation with no difference in hemodynamic variables. Trial registration number ClinicalTrials.gov (PROSPERO No. CRD42024529980).
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