Laboratory study demonstrates that GSTpi suppresses TNF-α-induced endothelial permeability by inhibiting p38MAPK/HSP27 signaling, highlighting a protective role in vascular barrier function.
GSTpi inhibited TNF-α-induced actin remodeling, stress fiber formation and endothelial permeability increase by inhibiting the p38MAPK/HSP27 signaling pathway.
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Yang et al. (2018) studied this question.
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