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August 18, 2007Circulation Research

Differential Regulation of Endothelial Cell Permeability by cGMP via Phosphodiesterases 2 and 3

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Population

Endothelial cells

Comparison

Varying concentrations of cGMP, PDE3A… vs Control conditions

Design

Preclinical

Authors

JSJames SurapisitchatUniversity Health NetworkKJKye‐Im JeonUniversity of South FloridaYCYan ChenMacau University of Science and Technology

Discussion

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Implication

Biphasic cGMP-PDE effects on permeability may guide future inhibitor dosing; leaves open human translation from animal models.

Structured PICO

P
Population
Endothelial cells
I
Intervention
Varying concentrations of cGMP (via atrial natriuretic peptide or NO donors), PDE3A inhibitors, PDE2A inhibitors, and tumor necrosis factor-alpha
C
Comparator
Control conditions (e.g., thrombin-induced permeability without modulators)
O
Outcome
Endothelial cell permeabilitysurrogate

The study demonstrates that cGMP exerts a biphasic effect on endothelial permeability depending on its concentration and the relative expression of PDE2A and PDE3A.

Cite This Study

Surapisitchat et al. (2007) studied this question.

synapsesocial.com/papers/6a7e805eb2811efa75cd9b28https://doi.org/10.1161/circresaha.107.154229
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Also Consider

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  1. 1Expression of cGMP-Dependent Protein Kinase I and Phosphorylation of Its Substrate, Vasodilator-Stimulated Phosphoprotein, in Human Endothelial Cells of Different Origin1995 · 118 citations
  2. 2Cyclic GMP regulation of the L‐type Ca<sup>2+</sup> channel current in human atrial myocytes2001 · 153 citations
  3. 3Nitric oxide attenuates H<sub>2</sub>O<sub>2</sub>-induced endothelial barrier dysfunction: mechanisms of protection2001 · 29 citations
  4. 4Endothelial nitric oxide synthase activation is critical for vascular leakage during acute inflammation <i>in vivo</i>2005 · 143 citations
  5. 5Vascular endothelium is critically involved in the hypotensive and hypovolemic actions of atrial natriuretic peptide2005 · 171 citations