Does metformin reduce cardiac fibrosis and collagen synthesis in in vivo pressure overload models and cardiac fibroblasts?
Metformin attenuates cardiac fibrosis via inhibition of the TGFβ1–Smad3 signalling pathway, providing a new mechanism for its cardioprotective effects.
Metformin inhibited cardiac fibrosis induced by pressure overload in vivo and inhibited collagen synthesis in CFs probably via inhibition of the TGF-beta(1)-Smad3 signalling pathway. These findings provide a new mechanism for the cardioprotective effects of metformin.
Xiao et al. (Wed,) studied this question.