Why the study?
Does metformin reduce cardiac fibrosis and collagen synthesis in in vivo pressure overload models and cardiac fibroblasts?
Does metformin reduce cardiac fibrosis and collagen synthesis in in vivo pressure overload models and cardiac fibroblasts?
Metformin attenuates cardiac fibrosis via inhibition of the TGFβ1–Smad3 signalling pathway, providing a new mechanism for its cardioprotective effects.
Provides mechanistic support in animal models; leaves open applicability to human cardiac fibrosis.
Metformin inhibited cardiac fibrosis induced by pressure overload in vivo and inhibited collagen synthesis in CFs probably via inhibition of the TGF-beta(1)-Smad3 signalling pathway. These findings provide a new mechanism for the cardioprotective effects of metformin.
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Xiao et al. (2010) studied this question.
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