What question did this study set out to answer?

Determine the independent prognostic significance of the total number of metastatic lymph nodes on overall survival in patients surgically treated for oral cavity squamous cell carcinoma.

September 7, 2017Journal of Clinical Oncology

Metastatic Lymph Node Burden and Survival in Oral Cavity Cancer

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Determine the independent prognostic significance of the total number of metastatic lymph nodes on overall survival in patients surgically treated for oral cavity squamous cell carcinoma.
Analyzed 14,554 adult patients with oral cavity squamous cell carcinoma undergoing upfront curative surgical resection and neck dissection with at least 10 lymph nodes examined from the National Cancer Data Base (2004–2013).
Constructed multivariable survival models and applied recursive partitioning analysis, adjusting for nodal size, laterality, extranodal extension, surgical margins, and adjuvant therapy.
Mortality risk rose continuously with each additional positive node without a plateau, showing the strongest effect through four metastatic nodes (HR, 1.34; 95% CI, 1.29 to 1.39; P < .001).
Extranodal extension (HR, 1.41; 95% CI, 1.20 to 1.65; P < .001) and lower neck involvement (HR, 1.16; 95% CI, 1.06 to 1.27; P < .001) independently predicted mortality, whereas nodal size and contralateral involvement lost statistical significance after adjusting for positive node count.

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Implication

Cohort study reveals increasing metastatic lymph node count continuously worsens survival in oral cavity cancer, indicating total positive node burden outclasses traditional size and laterality...

Cite This Study

Ho et al. (2017) studied this question.

synapsesocial.com/papers/69dbbed33d9adb00e7684df7 https://doi.org/10.1200/jco.2016.71.1176

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Implication

Cohort study reveals increasing metastatic lymph node count continuously worsens survival in oral cavity cancer, indicating total positive node burden outclasses traditional size and laterality...

Metastatic Lymph Node Burden and Survival in Oral Cavity Cancer

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Discussion

Implication

Cite This Study

Metastatic Lymph Node Burden and Survival in Oral Cavity Cancer

Key Points

Discussion

Implication

Cite This Study

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