Does deferring revascularization based on CFR ≥2.0 in lesions with FFR ≤0.8 result in noninferior outcomes compared to lesions with FFR >0.8 and CFR ≥2.0?
The results do not support using invasive CFR ≥2.0 to defer revascularization for lesions with reduced FFR (≤0.8).
All-cause death, myocardial infarction, and revascularization after 2 years was not noninferior between lesions with FFR ≤0.8 but CFR ≥2.0 and lesions with FFR >0.8 and CFR ≥2.0. These results do not support using invasive CFR ≥2.0 to defer revascularization for lesions with reduced FFR if the patient would otherwise be a candidate on the basis of the entire clinical scenario and treatment preference.
Johnson et al. (Wed,) studied this question.
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